THE VOLUME OF THREE-DIMENSIONAL CULTURES OF CANCER CELLS IN VITRO INFLUENCES TRANSCRIPTIONAL PROFILE DIFFERENCES AND SIMILARITIES WITH MONOLAYER CULTURES AND XENOGRAFTED TUMORS

Improving the congruity of preclinical models with cancer as it is manifested in humans is a potential way to mitigate the high attrition rate of new cancer therapies in the clinic.In this regard, three-dimensional (3D) tumor cultures in vitro have recently regained interest as they have been acclaimed to have higher similarity to tumors in vivo th

Traumatic brain injury (TBI) has become a leading cause of mortality, morbidity and disability worldwide.Hydroxysafflor yellow A (HSYA) is effective in treating TBI, but the potential koala shoes factory outlet mechanisms require further exploration.We aimed to reveal the mechanisms of HSYA against acute TBI by an integrated strategy combining meta

Despite considerable progress in face recognition technology in recent years, deep learning (DL) and convolutional neural juicy licorice networks (CNN) have revealed commendable recognition effects with the advent of artificial intelligence and big data.FaceNet was presented in 2015 and is able to significantly improve the accuracy of face recognit

This paper quantifies the benefits of flattening the curve (with a constant total patient load over the study period) on the risk of a hospital bed shortage in a pandemic.Using discrete-event simulation of patient care paths in hospitals, synthetic data that eliminates issues of confounding affects from the simultaneous occurrence of regional respo